EpiFluid Lab The dark matter of the genome -- Understand the non-coding genetic variants by multi-omics inside and outside the cells.


The lab is moving to the Simpson Querrey Institute for Epigenetics, Department of Biochemistry and Molecular Genetics at the Northwestern University Feinberg School of Medicine (starting at 9/1/2023). We are epigenomics and computational biology lab within the Division of Human Genetics and Biomedical Informatics in the Cincinnati Children’s Hospital Medical Center (CCHMC) and also part of the Department of Pediatrics in University of Cincinnati College of Medicine. The research focus of our lab is on developing and applying computational and experimental multi-omic methods to understand the gene regulation of non-coding genetic variants. Specifically, we would like to utilize multi-dimensional epigenomics signals within the single cells and that from circulating cell-free DNA (outside cells) to dissect the functional roles of non-coding regulatory elements and therefore bridge the gaps between genetic variations and phenotypic variations at different physiological and pathological conditions.