EpiFluid Lab

Epigenomics & Liquid Biopsy


We are epigenomics and computational biology lab within the Division of Human Genetics and Biomedical Informatics in the Cincinnati Children’s Hospital Medical Center (CCHMC) and also part of the Department of Pediatrics in University of Cincinnati College of Medicine.


The focus of the lab is on developing and applying machine learning and high-throughput experimental methods to understand the gene regulation and non-coding genetic variants. Specifically, we would like to understand the multi-omics heterogeneity in circulating cell-free DNA and its related cell types at single-cell resolution to explore the role of epigenetics in gene regulation and therefore bridge the gap between genetic and phenotypic variations at different healthy and pathological conditions.

Recent news

Dr. Xionghui Zhou’s preprint manuscript on cell-free DNA fragmentation hotspots in early-stage cancer is online at BioRxiv now.